General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/CRF2/G15 Stable Cell L
Recombinant CHO-K1 cells stably overexpress human corticotropin releasing hormone receptor 2 (CRF2) on the surface and contain high levels of G protein G s to couple with the receptor in downstream signaling pathways
Apexbio Technology LLC NFAT Inhibitor 249537-73-3 1mg
NFAT Inhibitor (CAS 249537-73-3) is a selective small molecule that blocks the calcineurin-dependent dephosphorylation of the nuclear factor of activated T cells (NFAT) thereby preventing its activation Unlike general calcineurin inhibitors this compound does not interfere with other calcineurin-mediated signaling pathways By inhibiting NFAT activation it reduces the expression of NFAT-dependent cytokine genes in T cells NFAT Inhibitor is valuable for studying the specific roles of NFAT signaling in immune cell function and for dissecting calcineurin-related pathways in immunological and cellular research
Biochain Institute Inc Frozen Tissue Section - Parkinson's Disease: Brain: Cerebellum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Matched Pair - Total RNA - Human Primary and Metastatic Tumor Tissue: Colon, 2x10 ug/PK
BioChain's human total RNA matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of total RNA isolated from primary tumor and its adjacent normal tissue; PM consists of total RNA from primary tumor and and corresponding metastatic tumor. Total RNA in each pair is prepared from the same donor. This product line is designed for identifying tumor-specific genes and tumor metastatic genes.
Eurofins Discoverx PathHunter CHO-K1 THRα Protein Interaction Cell Line, 2 vials. (93-0324C2)
The PathHunter THRα Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. triiodothyronine) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. The included cell line overexpresses ProLink-tagged THRα NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of THRα, induced interaction with SRCP leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/nhr.
ATCC C166; Yolk-Sac Endothelial Cells; Mouse (Mus musculus)
C166 is an endothelial cell line that was isolated from the yolk sac of a 12-day-old, mouse embryo. This cell line was deposited by R Auerbach and can be used in cardiovascular disease and stem cell research.
ATCC Salmonella enterica; subsp. enterica; serovar Saintpaul
Salmonella enterica subsp. enterica serovar Saintpaul strain 127 was isolated from a case of cystitis in Panama. This strain is serotype 1,4,5,12:e,h:1,2 and has applications in enteric disease research.
Sciencell Research Laboratories Human Intestinal Fibroblasts, Cat. #2920, >5 x 10^5 cells/vial, 1 ml, Spindle morphology, Cryopreserved at passage one
Human Intestinal Fibroblasts, Cat. #2920, >5 x 10^5 cells/vial, 1 ml, Spindle morphology, Cryopreserved at passage one
Cellular Dynamics International iCELL MACROPHAGES 2.0 Kit, Macrophage cell type, human, ≥ 1 x 10^6 viable cells, >90% CD68+ purity, up to 14 days culture duration
iCELL MACROPHAGES 2.0 Kit, Macrophage cell type, human, ≥ 1 x 10^6 viable cells, >90% CD68+ purity, up to 14 days culture duration
Eurofins Discoverx ChemiScreen M3 Muscarinic Acetylcholine Receptor Membrane Preparation, 1 vial. (HTS116M)
The ChemiScreen M3 Muscarinic Acetylcholine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CHRM3 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx PathHunter CHO-K1 mCXCR2 (IL8RB) β-Arrestin Cell Line, 2 vials. (93-0513C2)
The PathHunter mCXCR2 (IL8RB) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL-8) based activation of mCXCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCXCR2 and EA-tagged β-Arrestin-2. Activation of mCXCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Amsbio LLC Lyophilized exosomes from Plasma of Healthy donors
Lyophilized exosomes from Plasma of Healthy donors
Eurofins Discoverx PathHunter U2OS OSMR/IL6ST Dimerization Cell Line, 2 vials. (93-1056C3)
The PathHunter OSMR/IL6ST Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. oncostatin M) induced dimerization of OSMR/IL6ST receptors. This product uses EFC technology. The cell line included overexpresses IL6ST target protein fused to PK alongside OSMR target protein fused to EA. Upon ligand-induced dimerization of OSMR/IL6ST, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
ATCC Mycobacterium avium; subsp. avium
Mycobacterium avium subsp. avium strain Vet. 1387 [SSC 1336, TMC 724] was isolated from the liver of a diseased hen. This product is a type strain that can be used in agricultural research.
ATCC Cryptosporidium parvum; Quantitative DNA
Quantitative Genomic DNA from Cryptosporidium parvum can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine protozoan load and for other molecular biology applications.